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【正文】 al of DNA damages: utraviolet (UV) irradiation induced thymine/pyrimidine dimmersphotoactivation。Wele to My Molecular Biology Class Molecular Biology of the Gene, 5/E Watson et al. (2023) Part I: Chemistry and Geics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods 3/22/05 Part II: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next Ch 6: The structures of DNA and RNA Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous rebination at the molecular level Ch 11: Sitespecific rebination and transposition of DNA 3/22/05 The consequence of high rates of mutation ? Mutation in germ line (生殖細(xì)胞 ) would destroy the species ? Mutation in soma (體細(xì)胞 ) would destroy the individual. Maintenance of the correctness of the DNA sequence is definitely crucial for living anisms. Keeping the error rate as low as 1010 (page191) is very expensive. Build up a serious attitude to science!!! I absolutely do not agree with Waston et al. at the points described 3rd 4th paragraphs on page 235 1. What are the more reasonable explanations for the 1010 mutation frequency in living anisms? 2. What are the evidences that such a low mutation rate can drive the evolvement of a new species if the cell changes are known harmful? Listening to nature ? Mutation (突變 ) is naturally avoided by repair of the errors and damages, suggesting it is generally not wele in living anisms. ? Rebination (重組 ) is good and naturally promoted。 alkylation agents caused O6methylguaninemethyl transferase. Base excision repair: the base damage by alkylation and oxidation Nucleotide excision repair: the distortion of the DNA double helix by thymine dimmer or the bulky chemical adduct (加合物 ) on a base. Rebination repair: doublestrand breaks in DNA, errors encountered by a replication fork. Translesion synthesis allows the replication to proceed across DNA damage at a cost of errorprone replication. A different DNA polymerase is utilized. CHAPTER 9 The mutability and repair of DNA Review the lecture Homework CHAPTER 9 The mutability and repair of DNA 演講完畢，謝謝觀看！。 (2) no mechanism to correct it。 it is responsible for diversity inside of species. ? Transposition (轉(zhuǎn)座 ) is different from mutation and rebination because (1) producing mechanism is differ

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