年產4200噸環氧氯丙烷車間合成工藝設計-資料下載頁

　　

【正文】 centration of a chemical in air to which exposure for a specific length of time is expected to cause death in 50% of a defined experimental animal population. LOAELLowestobservedadverseeffect level. NIOSH IDLHNational Institute of Occupational Safety and Health39。s immediately dangerous to life or health limit。 NIOSH remended exposure limit to ensure that a worker can escape from an exposure condition that is likely to cause death or immediate or delayed permanent adverse health effects or prevent escape from the environment. NOAELNoobservedadverseeffect level. OSHA PELOccupational Safety and Health Administration39。s permissible exposure limit expressed as a timeweighted average。 the concentration of a substance to which most workers can be exposed without adverse effect averaged over a normal 8h workday or a 40h workweek. The health and regulatory values cited in this factsheet were obtained in December 1999.a Health numbers are toxicological numbers from animal testing or risk assessment values developed by EPA. b Regulatory numbers are values that have been incorporated in Government regulations, while advisory numbers are nonregulatory values provided by the Government or other groups as advice. OSHA numbers are regulatory, whereas NIOSH, ACGIH, and AIHA numbers are advisory. c This NOAEL and LOAEL are from the critical study used as the basis for the RfC. References. Environmental Protection Agency. Health and Environmental Effects Profile for Epichlorohydrin. EPA/600/x85/400. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1985. . Environmental Protection Agency. Integrated Risk Information System (IRIS) on Epichlorohydrin. National Center for Environmental Assessment, Office of Research and Development, Washington, DC. 1999. International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man: Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics. Volume 11. World Health Organization, Lyon. 1976. . Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993. . Environmental Protection Agency. Epichlorohydrin Health Advisory. Office of Drinking Water, Washington, DC. 1987. . Environmental Protection Agency. Health Effects Assessment Summary Tables. FY 1997 Update. Solid Waste and Emergency Response, Office of Emergency and Remedial Response, Cincinnati, OH. EPA/540/R97036. 1997. The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals. 11th ed. Ed. S. Budavari. Merck and Co. Inc., Rahway, NJ. 1989. . Amoore and E. Hautala. Odor as an aid to chemical safety: Odor thresholds pared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution. Journal of Applied Toxicology, 3(6):272290. 1983. American Conference of Governmental Industrial Hygienists (ACGIH). 1999 TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents. Biological Exposure Indices. Cincinnati, OH. 1999. National Institute for Occupational Safety and Health (NIOSH). Pocket Guide to Chemical Hazards. . Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention. Cincinnati, OH. 1997. Occupational Safety and Health Administration (OSHA). Occupational Safety and Health Standards, Toxic and Hazardous Substances. Code of Federal Regulations. 29 CFR . 1998. American Industrial Hygiene Association (AIHA). The AIHA 1998 Emergency Response Planning Guidelines and Workplace Environmental Exposure Level Guides Handbook. 1998. 空氣中的有毒物質 環氧氯丙烷（ 1 氯2,3 環氧丙烷） 10689Chronic Effects (NoncancHazard SummaryCreated in April 1992。 Revised in January 2000危險的主要信息創建于1992年4月。調整是在2000年1月 Epichlorohydrin is mainly used in the production of epoxy resins. Acute (shortterm) inhalation exposure to epichlorohydrin in the workplace has caused irritation to the eyes, respiratory tract, and skin of workers. At high levels of exposure, nausea, vomiting, cough, labored breathing, inflammation of the lung, pulmonary edema, and renal lesions may be observed in humans. Chronic (longterm) occupational exposure of humans to epichlorohydrin in air is associated with high levels of respiratory tract illness and hematological effects. Damage to the nasal passages, respiratory tract and kidneys have been observed in rodents exposed to epichlorohydrin by inhalation for acute or chronic duration. An increased incidence of tumors of the nasal cavity has been observed in rats exposed by inhalation. EPA has classified epichlorohydrin as a Group B2, probable human ，主要用于生產環氧樹脂。急性（短期）吸入接觸環氧氯丙烷在工作場所已引起刺激眼睛，呼吸道及皮膚的工人。在高層次的接觸，惡心，嘔吐，咳嗽， labored呼吸，發炎，肺癌，肺水腫，腎臟病變，可觀察到人類。慢性（長期）職業暴露人類環氧氯丙烷在空氣中是相關的高水平的呼吸道的疾病和血液的效果。損害鼻腔通道，呼吸道和腎臟已經觀察到，在嚙齒動物暴露于環氧氯丙烷吸入急性或慢性期。 1發病率增加腫瘤的鼻腔一直在觀察大鼠暴露出來的吸入。環保局已列為環氧氯丙烷作為一個群體， B2的，可能的人類致癌物質。 Please Note: The main sources of information for this fact sheet are EPA39。s IRIS , which contains information on inhalation chronic toxicity and carcinogenic effects of epichlorohydrin and the RfC , and unit cancer risk estimate for inhalation exposure, and the Health and Environmental Effects Profile for Epichlorohydrin .說明：主要的信息來源，這一事實表是EPA的虹膜，其中包含的信息吸入慢性毒性和致癌作用和環氧氯丙烷的RFC，本單位的患癌癥的風險估計為吸入性接觸，以及健康及環境的影響概況為環氧氯丙烷 。 Uses用途 The primary use of epichlorohydrin is in the production of epoxy resins used in coatings, adhesives, and ，粘合劑，和塑料工業。 ( 1 , 5 )Epichlorohydrin is also used in the manufacture of synthetic glycerine, textiles, paper, inks and dyes, solvents, surfactants, and ，紡織品，紙張，油墨和料，溶劑，表面活性劑和